Generalization and discrimination of inhibitory avoidance differentially engage anterior and posterior retrosplenial subregions.

ABSTRACT:

Introduction

In a variety of behavioral procedures animals will show selective fear responding in shock-associated contexts, but not in other contexts. However, several factors can lead to generalized fear behavior, where responding is no longer constrained to the conditioning context and will transfer to novel contexts.

Methods

Here, we assessed memory generalization using an inhibitory avoidance paradigm to determine if generalized avoidance behavior engages the retrosplenial cortex (RSC). Male and female Long Evans rats received inhibitory avoidance training prior to testing in the same context or a shifted context in two distinct rooms; one room that had fluorescent lighting (Light) and one that had red LED lighting (Dark).

Results

We found that animals tested in

SUBMITTER: Met Hoxha E 

PROVIDER: S-EPMC10832059 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature