A time window for rescuing dying retinal ganglion cells.

ABSTRACT:

Background

Retinal ganglion cell (RGC) degeneration and death cause vision loss in patients with glaucoma. Regulated cell death, once initiated, is generally considered to be an irreversible process. Recently, we showed that, by timely removing the cell death stimulus, stressed neuronal PC12 cells can recover from phosphatidylserine (PS) exposure, nuclear shrinkage, DNA damage, mitochondrial fragmentation, mitochondrial membrane potential loss, and retraction of neurites, all hallmarks of an activated cell death program. Whether the cell death process can be reversed in neurons of the central nervous system, like RGCs, is still unknown. Here, we studied reversibility of the activated cell death program in primary rat RGCs (prRGCs).

Methods

prRGCs were exposed to ethanol (5%,

SUBMITTER: You W 

PROVIDER: S-EPMC10832163 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature