Profiling of T cell repertoire in peripheral blood of patients from type 2 diabetes with complication.

ABSTRACT:

Purpose

More than 90% of patients with diabetes worldwide are type 2 diabetes (T2D), which is caused by insulin resistance or impaired producing insulin by pancreatic β cells. T2D and its complications, mainly large cardiovascular (LCV) and kidney (Ne) complications, are the major cause of death in diabetes patients. Recently, the dysregulation of peripheral T cell immune homeostasis was found in most T2D patients. However, the characteristics of T-cell receptors (TCR) remain largely unexplored in T2D patients.

Patients and methods

Here we investigated the TCR repertoire using high-throughput sequencing in peripheral blood collected from T2D patient with (8 LCV and 7 Ne) or without complications.

Results

Our analysis of TCR repertoires in peripheral blood samples show

SUBMITTER: Yin Y 

PROVIDER: S-EPMC10832173 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature