Identification of differentially methylated regions associated with both liver fibrosis and hepatocellular carcinoma.

ABSTRACT:

Background

Liver fibrosis is a major risk factor for hepatocellular carcinoma (HCC). We have previously reported that differentially methylated regions (DMRs) are correlated with the fibrosis stages of metabolic dysfunction-associated steatotic liver disease (MASLD). In this study, the methylation levels of those DMRs in liver fibrosis and subsequent HCC were examined.

Methods

The methylation levels of DMRs were investigated using alcoholic cirrhosis and HCC (GSE60753). The data of hepatitis C virus-infected cirrhosis and HCC (GSE60753), and two datasets (GSE56588 and GSE89852) were used for replication analyses. The transcriptional analyses were performed using GSE114564, GSE94660, and GSE142530.

Results

Hypomethylated DMR and increased transcriptional level of zinc

SUBMITTER: Kurokawa S 

PROVIDER: S-EPMC10832174 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature