Plasma fibroblast activation protein is decreased in acute heart failure despite cardiac tissue upregulation.

ABSTRACT:

Background

Cardiac fibroblast activation protein (FAP) has an emerging role in heart failure (HF). A paradoxical reduction in its levels in pathological conditions associated with acute processes has been observed. We aimed to identify FAP cardiac tissue expression and its relationship with the main cardiac fibrosis-related signaling pathways, and to compare plasma FAP levels in acute and chronic HF patients.

Methods

Transcriptomic changes were assessed via mRNA/ncRNA-seq in left ventricle tissue from HF patients (n = 57) and controls (n = 10). Western blotting and immunohistochemistry were used to explore FAP protein levels and localization in cardiac tissue. ELISA was performed to examine plasma FAP levels in acute HF (n = 48), chronic HF (n = 15) and control samples (n = 

SUBMITTER: Delgado-Arija M 

PROVIDER: S-EPMC10832198 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature