Changes in microbial composition and interaction patterns of female urogenital tract and rectum in response to HPV infection.

ABSTRACT:

Background

Previous studies have shown that changes in the microbial community of the female urogenital tract are associated with Human papillomavirus (HPV) infection. However, research on this association was mostly focused on a single site, and there are currently few joint studies on HPV infection and multiple sites in the female urogenital tract.

Methods

We selected 102 healthy women from Yunnan Province as the research object, collected cervical exfoliation fluid, vaginal, urethral, and rectal swabs for microbial community analysis, and measured bacterial load, and related cytokine content. The link between HPV, microbiota, and inflammation was comprehensively evaluated using bioinformatics methods.

Findings

The impact of HPV infection on the microbial compositio

SUBMITTER: Dong YH 

PROVIDER: S-EPMC10832222 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature