ZNF148 inhibits HBV replication by downregulating RXRα transcription.

ABSTRACT:

Background

Progressive hepatitis B virus (HBV) infection can result in cirrhosis, hepatocellular cancer, and chronic hepatitis. While antiviral drugs that are now on the market are efficient in controlling HBV infection, finding a functional cure is still quite difficult. Identifying host factors involved in regulating the HBV life cycle will contribute to the development of new antiviral strategies. Zinc finger proteins have a significant function in HBV replication, according to earlier studies. Zinc finger protein 148 (ZNF148), a zinc finger transcription factor, regulates the expression of various genes by specifically binding to GC-rich sequences within promoter regions. The function of ZNF148 in HBV replication was investigated in this study.

Methods

HepG2-Na⁺

SUBMITTER: Yao X 

PROVIDER: S-EPMC10832224 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature