Inbreeding depression is associated with recent homozygous-by-descent segments in Belgian Blue beef cattle.

ABSTRACT:

Background

Cattle populations harbor generally high inbreeding levels that can lead to inbreeding depression (ID). Here, we study ID with different estimators of the inbreeding coefficient F, evaluate their sensitivity to used allele frequencies (founder versus sample allele frequencies), and compare effects from recent and ancient inbreeding.

Methods

We used data from 14,205 Belgian Blue beef cattle genotyped cows that were phenotyped for 11 linear classification traits. We computed estimators of F based on the pedigree information (F_PED), on the correlation between uniting gametes (F_UNI), on the genomic relationship matrix (F_GRM), on excess homozygosity (F_HET), or on homozygous-by-descent (HBD) segments (F_HBD).

Resu

SUBMITTER: Naji MM 

PROVIDER: S-EPMC10832232 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature