The role of microRNAs in understanding sex-based differences in Alzheimer's disease.

ABSTRACT:

Background

The incidence of Alzheimer's disease (AD)-the most frequent cause of dementia-is expected to increase as life expectancies rise across the globe. While sex-based differences in AD have previously been described, there remain uncertainties regarding any association between sex and disease-associated molecular mechanisms. Studying sex-specific expression profiles of regulatory factors such as microRNAs (miRNAs) could contribute to more accurate disease diagnosis and treatment.

Methods

A systematic review identified six studies of microRNA expression in AD patients that incorporated information regarding the biological sex of samples in the Gene Expression Omnibus repository. A differential microRNA expression analysis was performed, considering disease status and pa

SUBMITTER: Llera-Oyola J 

PROVIDER: S-EPMC10832236 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature