Metabolomics and transcriptomics of embryonic livers reveal hypoxia adaptation of Tibetan chickens.

ABSTRACT:

Background

Exploring the hypoxia adaptation mechanism of Tibetan chicken is of great significance for revealing the survival law of Tibetan chicken and plateau animal husbandry production. To investigate the hypoxia adaptation of Tibetan chickens (TBCs), an integrative metabolomic-transcriptomic analysis of the liver on day 18 of embryonic development was performed. Dwarf laying chickens (DLCs), a lowland breed, were used as a control.

Results

A total of 1,908 metabolites were identified in both TBCs and DLCs. Energy metabolism and amino acid metabolism related differentially regulated metabolites (DRMs) were significantly enriched under hypoxia. Important metabolic pathways including the TCA cycle and arginine and proline metabolism were screened; PCK1, SUCLA2, and CPS1 wer

SUBMITTER: Xue M 

PROVIDER: S-EPMC10832288 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature