Elucidating systemic immune responses to acute and convalescent SARS-CoV-2 infection in children and elderly individuals.

ABSTRACT:

Background

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), a causative pathogen of the COVID-19 pandemic, affects all age groups. However, various studies have shown that COVID-19 presentation and severity vary considerably with age. We, therefore, wanted to examine the differences between the immune responses of children with COVID-19 and elderly COVID-19 individuals.

Methods

We analyzed cytokines, chemokines, growth factors, and acute phase proteins in acute and convalescent COVID-19 children and the elderly with acute and convalescent COVID-19.

Results

We show that most of the pro-inflammatory cytokines (interferon [IFN]γ, interleukin [IL]-2, tumor necrosis factor-α [TNFα], IL-1α, IFNα, IFNβ, IL-6, IL-12, IL-3, IL-7, IL-1Ra, IL-13, and IL-10), chemoki

SUBMITTER: Rajamanickam A 

PROVIDER: S-EPMC10832318 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature