Tracking Tumor Cell Dissemination from Lung Metastases Using Photoconversion.

ABSTRACT: Metastasis - the systemic spread of cancer - is the leading cause of cancer-related deaths. Although metastasis is commonly thought of as a unidirectional process wherein cells from the primary tumor disseminate and seed metastases, tumor cells in existing metastases can also redisseminate and give rise to new lesions in tertiary sites in a process known as "metastasis-from-metastases" or "metastasis-to-metastasis seeding." Metastasis-to-metastasis seeding may increase the metastatic burden and decrease the patient's quality of life and survival. Therefore, understanding the processes behind this phenomenon is crucial to refining treatment strategies for patients with metastatic cancer. Little is known about metastasis-to-metastasis seeding, due in part to logistical and technological limi

SUBMITTER: Friedman-DeLuca M 

PROVIDER: S-EPMC10832329 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature