Estimated rates of progression to tuberculosis disease for persons infected with Mycobacterium tuberculosis in the United States.

ABSTRACT:

Background

In the United States, over 80% of tuberculosis (TB) disease cases are estimated to result from reactivation of latent TB infection (LTBI) acquired more than 2 years previously ("reactivation TB"). We estimated reactivation TB rates for the US population with LTBI, overall, by age, sex, race-ethnicity, and US-born status, and for selected comorbidities (diabetes, end-stage renal disease, and HIV).

Methods

We collated nationally representative data for 2011-2012. Reactivation TB incidence was based on TB cases reported to the National TB Surveillance System that were attributed to LTBI reactivation. Person-years at risk of reactivation TB were calculated using interferon-gamma release assay (IGRA) positivity from the National Health and Nutrition Examination Survey,

SUBMITTER: Ekramnia M 

PROVIDER: S-EPMC10832387 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature