Screening and Validation of Key Genes of Autophagy in Acute Myocardial Infarction Based on Bioinformatics.

ABSTRACT:

Aims

Autophagy plays a significant role in the development of acute myocardial infarction (AMI), and cardiomyocyte autophagy is of major importance in maintaining cardiac function. We aimed to identify key genes associated with autophagy in AMI through bioinformatics analysis and verify them through clinical validation.

Materials and methods

We downloaded an AMI expression profile dataset GSE166780 from Gene Expression Omnibus (GEO). Autophagy-associated genes potentially differentially expressed in AMI were screened using R software. Then, to identify key autophagy-related genes, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, protein-protein interaction (PPI) analysis, Receiver Operating Characteristic (ROC) curve analysis, and co

SUBMITTER: Geng Y 

PROVIDER: S-EPMC10832399 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature