MicroRNA profile of extracellular vesicles released by Muller glial cells.

ABSTRACT:

Introduction

As with any other radial glia in the central nervous system, Müller glia derive from the same neuroepithelial precursors, perform similar functions, and exhibit neurogenic properties as radial glia in the brain. Müller glial cells retain progenitor-like characteristics in the adult human eye and can partially restore visual function upon intravitreal transplantation into animal models of glaucoma. Recently, it has been demonstrated that intracellular communication is possible via the secretion of nano-sized membrane-bound extracellular vesicles (EV), which contain bioactive molecules like microRNA (miRNA) and proteins that induce phenotypic changes when internalised by recipient cells.

Methods

We conducted high-throughput sequencing to profile the microRNA signa

SUBMITTER: Lamb WDB 

PROVIDER: S-EPMC10832456 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature