Causal association between snoring and stroke: a Mendelian randomization study in a Chinese population.

ABSTRACT:

Background

Previous observational studies established a positive relationship between snoring and stroke. We aimed to investigate the causal effect of snoring on stroke.

Methods

Based on 82,339 unrelated individuals with qualified genotyping data of Asian descent from the China Kadoorie Biobank (CKB), we conducted a Mendelian randomization (MR) analysis of snoring and stroke. Genetic variants identified in the genome-wide association analysis (GWAS) of snoring in CKB and UK Biobank (UKB) were selected for constructing genetic risk scores (GRS). A two-stage method was applied to estimate the associations of the genetically predicted snoring with stroke and its subtypes. Besides, MR analysis among the non-obese group (body mass index, BMI <24.0 kg/m²), as well as mu

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC10832459 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature