Two-step regulation by matrix Gla protein in brown adipose cell differentiation.

ABSTRACT:

Objective

Bone morphogenetic protein (BMP) signaling is intricately involved in adipose tissue development. BMP7 together with BMP4 have been implicated in brown adipocyte differentiation but their roles during development remains poorly specified. Matrix Gla protein (MGP) inhibits BMP4 and BMP7 and is expressed in endothelial and progenitor cells. The objective was to determine the role of MGP in brown adipose tissue (BAT) development.

Methods

The approach included global and cell-specific Mgp gene deletion in combination with RNA analysis, immunostaining, thermogenic activity, and in vitro studies.

Results

The results revealed that MGP directs brown adipogenesis at two essential steps. Endothelial-derived MGP limits triggering of white adipogenic differentiation in

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10832489 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature