Benefits and harms of polygenic risk scores in organised cancer screening programmes: a cost-effectiveness analysis.

ABSTRACT:

Background

While polygenic risk scores (PRS) could enable the streamlining of organised cancer screening programmes, its current discriminative ability is limited. We conducted a cost-effectiveness analysis to trade-off the benefits and harms of PRS-stratified cancer screening in China.

Methods

The validated National Cancer Center (NCC) modelling framework for six cancers (lung, liver, breast, gastric, colorectum, and oesophagus) was used to simulate cancer incidence, progression, stage-specific cancer detection, and risk of death. We estimated the number of cancer deaths averted, quality-adjusted life-years (QALY) gained, number needed to screen (NNS), overdiagnosis, and incremental cost-effectiveness ratio (ICER) of one-time PRS-stratified screening strategy (screening 25%

SUBMITTER: Xia C 

PROVIDER: S-EPMC10832505 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature