Increased heterogeneity in expression of genes associated with cancer progression and drug resistance.

ABSTRACT: Fluctuations in the number of regulatory molecules and differences in timings of molecular events can generate variation in gene expression among genetically identical cells in the same environmental condition. This variation, termed as expression noise, can create differences in metabolic state and cellular functions, leading to phenotypic heterogeneity. Expression noise and phenotypic heterogeneity have been recognized as important contributors to intra-tumor heterogeneity, and have been associated with cancer growth, progression, and therapy resistance. However, how expression noise changes with cancer progression in actual cancer patients has remained poorly explored. Such an analysis, through identification of genes with increasing expression noise, can provide valuable insights into

SUBMITTER: Bose A 

PROVIDER: S-EPMC10832509 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature