Tailoring modifications in labrenzin synthesis: a-la-carte production of pathway intermediates.

ABSTRACT: Pederin-family polyketides today constitute a group of more than 30 molecules being produced as natural products by different microorganisms across multitude of ecological niches. They are mostly known for their extreme cytotoxic activity and the decades of long exploration as potential antitumor drugs. The difference in their potency and biological activity lies in the tailoring modifications of the core molecule. Despite the isolation of many pederin-like molecules until the date, only marine bacterium Labrenzia sp. PHM005 was reported as a cultivable producer and able to be genetically modified. Here, we study the role of tailoring enzymes from the lab gene cluster responsible for methylation and hydroxylation of labrenzin core molecule. We managed to produce a spectrum of differently t

SUBMITTER: Kacar D 

PROVIDER: S-EPMC10832518 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature