From accurate genome sequence to biotechnological application: The thermophile Mycolicibacterium hassiacum as experimental model.

ABSTRACT: Mycobacteria constitute a large group of microorganisms belonging to the phylum Actinobacteria encompassing some of the most relevant pathogenic bacteria and many saprophytic isolates that share a unique and complex cell envelope. Also unique to this group is the extensive capability to use and synthesize sterols, a class of molecules that include active signalling compounds of pharmaceutical use. However, few mycobacterial species and strains have been established as laboratory models to date, Mycolicibacterium smegmatis mc² 155 being the most common one. In this work, we focus on the use of a thermophilic mycobacterium, Mycolicibacterium hassiacum, which grows optimally above 50°C, as an emerging experimental model valid to extend our general knowledge of mycobacterial biology

SUBMITTER: Sanchez-Costa M 

PROVIDER: S-EPMC10832570 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature