Impact of comorbidity on family genetic risk profiles for psychiatric and substance use disorders: a descriptive analysis.

ABSTRACT:

Background

- Comorbidity between psychiatric disorders is extensive but, from a genetic perspective, still poorly understood. Modern molecular genetic approaches to this problem are limited by a reliance on case-control designs.

Methods

- In 5 828 760 individuals born in Sweden from 1932-1995 with a mean (s.d.) age at follow-up of 54.4 (18.1), we examined family genetic risk score (FGRS) profiles including internalizing, psychotic, substance use and developmental disorders in 10 pairs of psychiatric and substance use disorders diagnosed from population registries. We examined these profiles in three groups of patients: disorder A only, disorder B only and comorbid cases with both disorders.

Results

- The most common pattern of findings, seen in five pairings, was simp

SUBMITTER: Kendler KS 

PROVIDER: S-EPMC10832607 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature