An unbiased approach of molecular characterization of the endometrium: toward defining endometrial-based infertility.

ABSTRACT: Infertility is a complex condition affecting millions of couples worldwide. The current definition of infertility, based on clinical criteria, fails to account for the molecular and cellular changes that may occur during the development of infertility. Recent advancements in sequencing technology and single-cell analysis offer new opportunities to gain a deeper understanding of these changes. The endometrium has a potential role in infertility and has been extensively studied to identify gene expression profiles associated with (impaired) endometrial receptivity. However, limited overlap among studies hampers the identification of relevant downstream pathways that could play a role in the development of endometrial-related infertility. To address these challenges, we propose sequencing the

SUBMITTER: Bui BN 

PROVIDER: S-EPMC10833067 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature