Patterns of publicly funded naltrexone use among patients diagnosed with alcohol use disorder in Ontario.

ABSTRACT:

Aims

Naltrexone is recommended first-line to manage alcohol use disorder (AUD). With previous studies indicating poor retention on naltrexone, we determined duration of naltrexone use and assessed the association between prescription setting and time to discontinuation in Ontario.

Methods

We conducted a retrospective population-based cohort study among Ontario public drug beneficiaries diagnosed with AUD who initiated publicly funded naltrexone from June 2018 to September 2019. The primary outcome was time to naltrexone discontinuation, with a secondary analysis assessing receipt of at least one prescription refill. We used Cox proportional hazards models and logistic regression to test the association between prescription setting and each medication persistence outcome.

SUBMITTER: Tourchian N 

PROVIDER: S-EPMC10833073 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature