The crystal structure of the human smacovirus 1 Rep domain.

ABSTRACT: Replication initiator proteins (Reps) from the HUH endonuclease family process specific single-stranded DNA sequences to initiate rolling-circle replication in viruses. Here, the first crystal structure of the apo state of a Rep domain from the smacovirus family is reported. The structure of the human smacovirus 1 Rep domain was obtained at 1.33 Å resolution and represents an expansion of the HUH endonuclease superfamily, allowing greater diversity in bioconjugation-tag applications.

SUBMITTER: Limon LK 

PROVIDER: S-EPMC10833120 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature