A tip-predominant distribution of villous intraepithelial lymphocytes is not specific to celiac disease in children with Marsh I lesions.

ABSTRACT:

Objectives

To assess if the distribution of villous intraepithelial lymphocytes (IELs) in a pediatric cohort with Marsh I histopathology is specific to celiac disease (CeD).

Methods

Multicenter, retrospective case-control study between January 2001 and December 2019 in children (<18 years) with and without CeD with intraepithelial lymphocytosis and normal villous architecture. Pathology specimens were reviewed by 2 study pathologists who were blinded to the final diagnosis. Morphologic features (villous height to crypt depth ratio [Vh:Cd]) and IELs in the villous tip, top, or bottom half of the villus were quantified.

Results

Of the 97 children with Marsh I histopathology identified during the study period, 63 were excluded due to an insufficient number of well-orient

SUBMITTER: Chang D 

PROVIDER: S-EPMC10833141 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature