Is phased implementation of HPV testing and triage with dual staining the way to transform organized cytology screening?

ABSTRACT:

Objective

The substantial material and legislative investments in establishing and maintaining cytological screening in the Czech Republic represent barriers to a direct transition to primary HPV screening. Therefore, the LIBUSE project was implemented to test the efficacy of phasing in HPV DNA testing as a co-test to cytology in routine screening of women >30 years of age.

Methods

Women aged 30 to 60 years who underwent regular annual Pap smears were co-tested for HPV DNA with selective 16/18 genotyping at 3-year intervals. All HPV 16/18-positive cases and/or cases with a severe abnormality in cytology were sent for colposcopy; HPV non-16/18-positive cases and LSILs were graded using p16/Ki67 dual-stain cytology, and positive cases were sent for colposcopy.

Results

O

SUBMITTER: Slama J 

PROVIDER: S-EPMC10833184 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature