Smdi: an R package to perform structural missing data investigations on partially observed confounders in real-world evidence studies.

ABSTRACT:

Objectives

Partially observed confounder data pose a major challenge in statistical analyses aimed to inform causal inference using electronic health records (EHRs). While analytic approaches such as imputation are available, assumptions on underlying missingness patterns and mechanisms must be verified. We aimed to develop a toolkit to streamline missing data diagnostics to guide choice of analytic approaches based on meeting necessary assumptions.

Materials and methods

We developed the smdi (structural missing data investigations) R package based on results of a previous simulation study which considered structural assumptions of common missing data mechanisms in EHR.

Results

smdi enables users to run principled missing data investigations on partially observed conf

SUBMITTER: Weberpals J 

PROVIDER: S-EPMC10833461 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature