Efficacy of short-course treatment for prevention of congenital transmission of Chagas disease: A retrospective cohort study.

ABSTRACT:

Background

In regions with controlled vector transmission of T. cruzi, congenital transmission is the most frequent route of infection. Treatment with benznidazole (BZ) or nifurtimox (NF) for 60 days in girls and women of childbearing age showed to be effective in preventing mother to child transmission of this disease. Reports on short-course treatment (≤30 days) are scarce.

Methods

Retrospective cohort study. Offspring of women with Chagas disease who received short-course treatment (≤30 days) with BZ or NF, attended between 2003 and 2022, were evaluated. Parasitemia (microhaematocrit and/or PCR) was performed at <8 months of age, and serology (ELISA and IHA) at ≥8 months to rule out congenital infection.

Results

A total of 27 women receiving ≤30 days of treatment a

SUBMITTER: Moscatelli G 

PROVIDER: S-EPMC10833510 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature