Diverse modulatory effects of bibenzyls from Dendrobium species on human immune cell responses under inflammatory conditions.

ABSTRACT: Dendrobium plants are widely used in traditional Chinese medicine. Their secondary metabolites such as bibenzyls and phenanthrenes show various pharmacological benefits such as immunomodulation and inhibitory effects on cancer cell growth. However, our previous study also showed that some of these promising compounds (i.e., gigantol and cypripedin) also induced the expression of inflammatory cytokines including TNF in human monocytes, and thus raising concerns about the use of these compounds in clinical application. Furthermore, the effects of these compounds on other immune cell populations, apart from monocytes, remain to be investigated. In this study, we evaluated immunomodulatory effects of seven known bibenzyl compounds purified from Dendrobium species in human peripheral blood mono

SUBMITTER: Kongkatitham V 

PROVIDER: S-EPMC10833532 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature