A Prospective Cohort Protocol for the Remnant Investigation in Sepsis Study.

ABSTRACT:

Background

Sepsis is a common and deadly syndrome, accounting for more than 11 million deaths annually. To mature a deeper understanding of the host and pathogen mechanisms contributing to poor outcomes in sepsis, and thereby possibly inform new therapeutic targets, sophisticated, and expensive biorepositories are typically required. We propose that remnant biospecimens are an alternative for mechanistic sepsis research, although the viability and scientific value of such remnants are unknown.

Methods and results

The Remnant Biospecimen Investigation in Sepsis study is a prospective cohort study of 225 adults (age ≥ 18 yr) presenting to the emergency department with community sepsis, defined as sepsis-3 criteria within 6 hours of arrival. The primary objective was to determi

SUBMITTER: Seymour CW 

PROVIDER: S-EPMC10833627 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature