Sexually dimorphic murine brain uptake of the 18 kDa translocator protein PET radiotracer [¹⁸F]LW223.

ABSTRACT: The 18 kDa translocator protein is a well-known biomarker of neuroinflammation, but also plays a role in homeostasis. PET with 18 kDa translocator protein radiotracers [¹¹C]PBR28 in humans and [¹⁸F]GE180 in mice has demonstrated sex-dependent uptake patterns in the healthy brain, suggesting sex-dependent 18 kDa translocator protein expression, although humans and mice had differing results. This study aimed to assess whether the 18 kDa translocator protein PET radiotracer [¹⁸F]LW223 exhibited sexually dimorphic uptake in healthy murine brain and peripheral organs. Male and female C57Bl6/J mice (13.6 ± 5.4 weeks, 26.8 ± 5.4 g, mean ± SD) underwent 2 h PET scanning post-administration of [¹⁸F]LW223 (6.7 ± 3.6 MBq). Volume of interest and parametric

SUBMITTER: Knyzeliene A 

PROVIDER: S-EPMC10833650 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature