Integrated meta-analysis of colorectal cancer public proteomic datasets for biomarker discovery and validation.

ABSTRACT: The cancer biomarker field has been an object of thorough investigation in the last decades. Despite this, colorectal cancer (CRC) heterogeneity makes it challenging to identify and validate effective prognostic biomarkers for patient classification according to outcome and treatment response. Although a massive amount of proteomics data has been deposited in public data repositories, this rich source of information is vastly underused. Here, we attempted to reuse public proteomics datasets with two main objectives: i) to generate hypotheses (detection of biomarkers) for their posterior/downstream validation, and (ii) to validate, using an orthogonal approach, a previously described biomarker panel. Twelve CRC public proteomics datasets (mostly from the PRIDE database) were re-analysed and

SUBMITTER: Robles J 

PROVIDER: S-EPMC10833860 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature