Intrinsic and extrinsic cues time somite progenitor contribution to the vertebrate primary body axis.

ABSTRACT: During embryonic development, the timing of events at the cellular level must be coordinated across multiple length scales to ensure the formation of a well-proportioned body plan. This is clear during somitogenesis, where progenitors must be allocated to the axis over time whilst maintaining a progenitor population for continued elaboration of the body plan. However, the relative importance of intrinsic and extrinsic signals in timing progenitor addition at the single-cell level is not yet understood. Heterochronic grafts from older to younger embryos have suggested a level of intrinsic timing whereby later staged cells contribute to more posterior portions of the axis. To determine the precise step at which cells are delayed, we performed single-cell transcriptomic analysis on heterochro

SUBMITTER: Busby L 

PROVIDER: S-EPMC10834026 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature