Early-life manganese exposure during multiple developmental periods and adolescent verbal learning and memory.

ABSTRACT:

Background

Manganese (Mn) is both an essential and toxic metal, and associations with neurodevelopment depend on exposure timing. Prospective data examining early life Mn with adolescent cognition are sparse.

Methods

We enrolled 140 Italian adolescents (10-14 years old) from the Public Health Impact of Metals Exposure study. Mn in deciduous teeth was measured using laser ablation-mass spectrometry to represent prenatal, postnatal and early childhood exposure. The California Verbal Learning Test for Children (CVLT-C) was administered to assess adolescent verbal learning and memory. Multivariable regression models estimated changes in CVLT-C scores and the odds of making an error per doubling in dentine Mn in each exposure period. Multiple informant models tested for differenc

SUBMITTER: Friedman A 

PROVIDER: S-EPMC10834060 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature