Comprehensive in silico functional specification of mouse retina transcripts.

ABSTRACT:

Background

The retina is a well-defined portion of the central nervous system (CNS) that has been used as a model for CNS development and function studies. The full specification of transcripts in an individual tissue or cell type, like retina, can greatly aid the understanding of the control of cell differentiation and cell function. In this study, we have integrated computational bioinformatics and microarray experimental approaches to classify the tissue specificity and developmental distribution of mouse retina transcripts.

Results

We have classified a set of retina-specific genes using sequence-based screening integrated with computational and retina tissue-specific microarray approaches. 33,737 non-redundant sequences were identified as retina transcript clusters (RTCs

SUBMITTER: Zhang SS 

PROVIDER: S-EPMC1083414 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature