Closed-loop stimulation in periods with less epileptiform activity drives improved epilepsy outcomes.

ABSTRACT: In patients with drug-resistant epilepsy, electrical stimulation of the brain in response to epileptiform activity can make seizures less frequent and debilitating. This therapy, known as closed-loop responsive neurostimulation (RNS), aims to directly halt seizure activity via targeted stimulation of a burgeoning seizure. Rather than immediately stopping seizures as they start, many RNS implants produce slower, long-lasting changes in brain dynamics that better predict clinical outcomes. Here we hypothesize that stimulation during brain states with less epileptiform activity drives long-term changes that restore healthy brain networks. To test this, we quantified stimulation episodes during low- and high-risk brain states-that is, stimulation during periods with a lower or higher risk of g

SUBMITTER: Anderson DN 

PROVIDER: S-EPMC10834245 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature