Cardiovascular effects of weight loss in old adults with overweight/obesity according to change in skeletal muscle mass.

ABSTRACT:

Background

Patients with overweight/obesity and type 2 diabetes are encouraged to lose weight, but not all losing weight gain better cardiovascular health, especially old adults. The change in skeletal muscle mass (SMM) could be the key that explains the heterogenous cardiovascular effects of weight loss. This study aims to assess whether the cardiovascular effects of weight loss vary for those gaining skeletal muscle along with weight loss.

Methods

The old adults with overweight/obesity and type 2 diabetes in the Look AHEAD study having muscle measurement from dual-energy X-ray absorptiometry were included. Based on the weight change (WC) and SMM change (SMMC) between baseline and the 4-year follow-up, participants were allocated into three groups-weight gain (WG) group, we

SUBMITTER: Cai X 

PROVIDER: S-EPMC10834329 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature