The mediation roles of intermuscular fat and inflammation in muscle mitochondrial associations with cognition and mobility.

ABSTRACT:

Background

Mitochondrial dysfunction may contribute to brain and muscle health through inflammation or fat infiltration in the muscle, both of which are associated with cognitive function and mobility. We aimed to examine the association between skeletal muscle mitochondrial function and cognitive and mobility outcomes and tested the mediation effect of inflammation or fat infiltration.

Methods

We analysed data from 596 Baltimore Longitudinal Study of Aging participants who had concurrent data on skeletal muscle oxidative capacity and cognitive and mobility measures of interest (mean age: 66.1, 55% women, 24% Black). Skeletal muscle oxidative capacity was assessed as post-exercise recovery rate (kPCr) via P31 MR spectroscopy. Fat infiltration was measured as intermuscular fa

SUBMITTER: Tian Q 

PROVIDER: S-EPMC10834332 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature