Obesity worsens mitochondrial quality control and does not protect against skeletal muscle wasting in murine cancer cachexia.

ABSTRACT:

Background

More than 650 million people are obese (BMI > 30) worldwide, which increases their risk for several metabolic diseases and cancer. While cachexia and obesity are at opposite ends of the weight spectrum, leading many to suggest a protective effect of obesity against cachexia, mechanistic support for obesity's benefit is lacking. Given that obesity and cachexia are both accompanied by metabolic dysregulation, we sought to investigate the impact of obesity on skeletal muscle mass loss and mitochondrial dysfunction in murine cancer cachexia.

Methods

Male C57BL/6 mice were given a purified high fat or standard diet for 16 weeks before being implanted with 10⁶ Lewis lung carcinoma (LLC) cells. Mice were monitored for 25 days, and hindlimb muscles were collect

SUBMITTER: Cardaci TD 

PROVIDER: S-EPMC10834333 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature