A multi-omics analysis of viral nucleic acid poly(I:C) responses to mammalian testicular stimulation.

ABSTRACT: The male reproductive system has a standard immune response regulatory mechanism, However, a variety of external stimuli, including viruses, bacteria, heat, and medications can damage the testicles and cause orchitis and epididymitis. It has been shown that various RNA viruses are more likely to infect the testis than DNA viruses, inducing orchitis and impairing testicular function. It was found that local injection of the viral RNA analog poly(I:C) into the testes markedly disrupted the structure of the seminiferous tubules, accompanied by apoptosis and inflammation. Poly(I:C) mainly inhibited the expression of testosterone synthesis-associated proteins, STAR and MGARP, and affected the synthesis and metabolism of amino acids and lipids in the testis. This led to the disruption of the met

SUBMITTER: Yang D 

PROVIDER: S-EPMC10834394 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature