Role of thrombospondin-1 in high-salt-induced mesenteric artery endothelial impairment in rats.

ABSTRACT: The matrix glycoprotein thrombospondin-1 (THBS1) modulates nitric oxide (NO) signaling in endothelial cells. A high-salt diet induces deficiencies of NO production and bioavailability, thereby leading to endothelial dysfunction. In this study we investigated the changes of THBS1 expression and its pathological role in the dysfunction of mesenteric artery endothelial cells (MAECs) induced by a high-salt diet. Wild-type rats, and wild-type and Thbs1^-/- mice were fed chow containing 8% w/w NaCl for 4 weeks. We showed that a high salt diet significantly increased THBS1 expression and secretion in plasma and MAECs, and damaged endothelium-dependent vasodilation of mesenteric resistance arteries in wild-type animals, but not in Thbs1^-/- mice. In rat MAECs, we demonstrated t

SUBMITTER: Xu FF 

PROVIDER: S-EPMC10834453 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature