Mitochondria as secretory organelles and therapeutic cargos.

ABSTRACT: Mitochondria have been primarily considered intracellular organelles that are responsible for generating energy for cell survival. However, accumulating evidence suggests that mitochondria are secreted into the extracellular space under physiological and pathological conditions, and these secreted mitochondria play diverse roles by regulating metabolism, the immune response, or the differentiation/maturation in target cells. Furthermore, increasing amount of research shows the therapeutic effects of local or systemic administration of mitochondria in various disease models. These findings have led to growing interest in exploring mitochondria as potential therapeutic agents. Here, we discuss the emerging roles of mitochondria as extracellularly secreted organelles to shed light on their fu

SUBMITTER: Suh J 

PROVIDER: S-EPMC10834547 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature