Adjuvant convection-enhanced delivery for the treatment of brain tumors.

ABSTRACT:

Background

Malignant gliomas are a therapeutic challenge and remain nearly uniformly fatal. While new targeted chemotherapeutic agentsagainst malignant glioma have been developed in vitro, these putative therapeutics have not been translated into successful clinical treatments. The lack of clinical effectiveness can be the result of ineffective biologic strategies, heterogeneous tumor targets and/or the result of poortherapeutic distribution to malignant glioma cells using conventional nervous system delivery modalities (intravascular, cerebrospinal fluid and/orpolymer implantation), and/or ineffective biologic strategies.

Methods

The authors performed a review of the literature for the terms "convection enhanced delivery", "glioblastoma", and "glioma". Selectclinical trials

SUBMITTER: Kreatsoulas D 

PROVIDER: S-EPMC10834622 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature