Development and verification of a combined immune- and cancer-associated fibroblast related prognostic signature for colon adenocarcinoma.

ABSTRACT:

Introduction

To better understand the role of immune escape and cancer-associated fibroblasts (CAFs) in colon adenocarcinoma (COAD), an integrative analysis of the tumor microenvironment was performed using a set of 12 immune- and CAF-related genes (ICRGs).

Methods

Univariate and least absolute shrinkage and selection operator (LASSO) Cox regression analyses were used to establish a prognostic signature based on the expression of these 12 genes (S1PR5, AEN, IL20RB, FGF9, OSBPL1A, HSF4, PCAT6, FABP4, KIF15, ZNF792, CD1B and GLP2R). This signature was validated in both internal and external cohorts and was found to have a higher C-index than previous COAD signatures, confirming its robustness a

SUBMITTER: Wei J 

PROVIDER: S-EPMC10834644 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature