Identification and validation of Golgi apparatus-related signature for predicting prognosis and immunotherapy response in breast cancer.

ABSTRACT:

Background

The Golgi apparatus plays a pivotal role in various aspects of cancer. This study aims to investigate the predictive value of Golgi apparatus-related genes (GARGs) in breast cancer prognosis and immunotherapy response evaluation.

Methods

Transcriptional and clinical data from the TCGA-BRCA cohort and GSE96058 cohort were utilized to construct and validate a prognostic model for breast cancer using Cox regression analysis. Differences in immune landscape, somatic mutations, gene expression, drug sensitivity, and immunotherapy response between different risk groups were assessed. A prognostic nomogram for breast cancer was further developed and evaluated. qPCR and single-cell sequencing analyses were performed to validate the expression of GARGs.

Results

A to

SUBMITTER: Chen X 

PROVIDER: S-EPMC10834659 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature