A mendelian randomization study investigates the causal relationship between immune cell phenotypes and cerebral aneurysm.

ABSTRACT: Background: Cerebral aneurysms (CAs) are a significant cerebrovascular ailment with a multifaceted etiology influenced by various factors including heredity and environment. This study aimed to explore the possible link between different types of immune cells and the occurrence of CAs. Methods: We analyzed the connection between 731 immune cell signatures and the risk of CAs by using publicly available genetic data. The analysis included four immune features, specifically median brightness levels (MBL), proportionate cell (PC), definite cell (DC), and morphological attributes (MA). Mendelian randomization (MR) analysis was conducted using the instrumental variables (IVs) derived from the genetic variation linked to CAs. Results: After multiple test adjustment based on

SUBMITTER: Shi X 

PROVIDER: S-EPMC10834707 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature