Non-invasive detection of lymphoma with circulating tumor DNA features and protein tumor markers.

ABSTRACT:

Background

According to GLOBOCAN 2020, lymphoma ranked as the 9^th most common cancer and the 12^th leading cause of cancer-related deaths worldwide. Traditional diagnostic methods rely on the invasive excisional lymph node biopsy, which is an invasive approach with some limitations. Most lymphoma patients are diagnosed at an advanced stage since they are asymptomatic at the beginning, which has significantly impacted treatment efficacy and prognosis of the disease.

Method

This study assessed the performance and utility of a newly developed blood-based assay (SeekInCare) for lymphoma early detection. SeekInCare utilized protein tumor markers and a comprehensive set of cancer-associated genomic features, including copy number aberration (CNA), fragment siz

SUBMITTER: Chang Y 

PROVIDER: S-EPMC10834776 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature