ENOX2 inhibition enhances infiltration of effector memory T-cell and mediates response to chemotherapy in immune-quiescent nasopharyngeal carcinoma.

ABSTRACT:

Introduction

The immunosuppressive tumor microenvironment is a major barrier for chemotherapy. Different chemosensitization approaches to reinstate immunological surveillance for cancers that are immune quiescent at the outset, have thus been devised. Cancer-specific ENOX2 expression is correlated with abnormal cell growth and has been proposed as a cellular target for anti-cancer activity. However, the potential effects of ENOX2 on the interaction between immune system and tumor cells remain elusive.

Objectives

To understand the mechanisms by which tumor-intrinsic ENOX2-mediated alterations in anti-tumor activity of T-cells and response to chemotherapy.

Methods

In situ multiplexed immunohistochemistry with single cell and bulk RNA sequencing data from nasopharyngeal

SUBMITTER: Kam NW 

PROVIDER: S-EPMC10834794 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature