A novel tree shrew model of lipopolysaccharide-induced acute respiratory distress syndrome.

ABSTRACT:

Introduction

Acute respiratory distress syndrome (ARDS) is a leading cause of respiratory failure, with substantial attributable morbidity and mortality. The small animal models that are currently used for ARDS do not fully manifest all of the pathological hallmarks of human patients, which hampers both the studies of disease mechanism and drug development.

Objectives

To examine whether the phenotypic changes of primate-like tree shrews in response to a one-hit lipopolysaccharides (LPS) injury resemble human ARDS features.

Methods

LPS was administered to tree shrews through intratracheal instillation; then, the animals underwent CT or PET/CT imaging to examine the changes in the structure and function of the whole lung. The lung histology was analyzed by H&E staining

SUBMITTER: He J 

PROVIDER: S-EPMC10834818 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature